NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety

Table 3 Telaprevir: clinical parameters

RCT	Dose frequency	Duration	SVR	Possible AE
Prove 1	Each 8 h, 6 t/d	24 wk: 12 wk of triple therapy, 12 wk of conventional treatment	61%	Rash, anemia, nausea, diarrhea
Advance	Every 8 h, 6 t/d	24-48 wk: 8-12 wk of viral response-based treatment followed by conventional treatment	69%-75%	Rash, anemia, nausea, diarrhea
Illuminate	Every 8 h, 6 t/d	24-48 wk: 12 wks of viral response-based treatment: 12 wk of triple therapy followed by conventional treatment	64%-92%	Rash, anemia, nausea, diarrhea
Optimize	Every 12 h, 6 t/d	24-48 wk: 12 wk of viral response-based treatment: 12 wk of triple therapy followed by conventional treatment for 12 to 36 wk	58%-81% (depending on fibrosis stage)	Rash, anemia, nausea

AE: Adverse event.