NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety

Table 13 Most common adverse event after 4 treatment weeks

	GS-9256 + tegobuvir	GS-9256 + tegobuvir + ribavirin by weight	GS-9256 + tegobuvir + ribavirin by weight + PEG-IFN1
AE incidence	50%	93%	81%-100%
Anemia	0	0	0-13%
Eye pain	0	0	0-13%
Diarrhea	19%	20%	6%-40%
Nausea	13%	20%	6%-40%
Flu-like syndrome	0	0	44%-80%
Fatigue	6%	33%	13%-33%
Headache	31%	47%	13%-40%
Insomnia	0	20%	6%-13%
Dry skin	0	13%	0%
Pruritus	6%	20%	0%-7%

¹Mean value of two CT phases. AE: Adverse event; PEG-IFN: PEGylated interferon.