Transient elastography: Kill two birds with one stone?

Table 2 Diagnostic performance and suggested cutoff values of controlled attenuation parameter for the diagnosis of liver steatosis

Ref.	Biopsies (n)	Study design	Etiologies	AUROC≥S1 (11%)	AUROC≥S2 (34%)	AUROC≥S3 (67%)	Cutoff values for≥S1 (dB/m)	Sen	Spe	NPV	PPV	Cutoff values for≥S2 (dB/m)	Sen	Spe	NPV	PPV	Cutoff values for≥S3 (dB/m)	Sen	Spe	NPV	PPV
Sasso et al[21], 2010	115	Retrospective	All	0.91	0.95	0.89	238	91%	81%	87%	87%	259	89%	86%	92%	80%	292	100%	78%	100%	28%
de Lédinghen et al[39], 2012	112	Prospective	All	0.84	0.86	0.93	215					252					296
Myers et al[40], 2012	153	Prospective	All	0.81			283	76%	79%	64%	87%
Beaugrand et al[41], 2010	74	Retrospective	ALD	0.81	0.87	0.82
Beaugrand et al[42], 2010	96	Retrospective	ALD/NAFLD	0.86	0.87	0.77
Cardoso et al[43], 2010	133	Retrospective	CHB	0.82	0.81	-
Sasso et al[44], 2012	615	Retrospective	CHC	0.8	0.86	0.88

ALD: Alcoholic liver disease; AUROC: Area under receiver operating characteristics curves; NPV: Negative predictive value; PPV: Positive predictive value; Sen: Sensitivity; Spe: Specificity; NAFLD: Non-alcoholic fatty liver disease; CHB: Chronic hepatitis B; CHC: Chronic hepatitis C.