Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis

Figure 5 Hepatocytic 8-hydroxydeoxyguanosine expression in patients with chronic liver disease. A: Hepatocytic 8-hydroxydeoxyguanosine labeling index was increased in the hepatitis C virus (HCV), autoimmune hepatitis (AIH), and primary biliary cirrhosis (PBC) groups (HCV, AIH or PBC vs normal; 64%, 64% or 68% vs 35%, respectively, ^aP < 0.05 vs normal), but not in the hepatitis B virus (HBV) group, and the labeling index was lower in the HBV than in the HCV group (HBV vs HCV; 41% vs 64%, respectively, ^dP < 0.001 vs HCV); B, C: The labeling indices of HBV and HCV samples were positively correlated with the staining intensity of hepatocytic nuclear apurinic/apyrimidinic endonuclease 1 (APE-1) protein (HBV, r = 0.34, P < 0.05; HCV, r = 0.54, P < 0.01).