Melatonin attenuates high fat diet-induced fatty liver disease in rats

Table 5 Effect of melatonin on laboratory indices

	Melatonin (5 mg/kg)	P value	Melatonin (10 mg/kg)	P value
Lipidemic profile
TC (mg/dL)	-10.7	0.45	-2.2	0.87
LDL (mg/dL)	-6.3	0.60	-3.9	0.74
HDL (mg/dL)	-5.3	0.10	1.9	0.52
TG (mg/dL)	6.7	0.71	-5.2	0.76
Hepatic function
AST (U/L)	-170	0.01	-224	0.001
ALT (U/L)	-62.9	0.01	-93.4	< 0.001
Oxidative profile
MDA	-12.7	< 0.001	-12.2	< 0.001
GSH	20.1	0.004	29.2	< 0.001

Multivariate linear regression analysis of melatonin effect after adjusting for duration of its use and high fat diet (HFD). Results are expressed as the mean difference between rats on melatonin by comparison to those not on melatonin. TC: Total cholesterol; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; TG: Triglycerides; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; MDA: Malondialdehyde; GSH: Glutathione.