Melatonin attenuates high fat diet-induced fatty liver disease in rats

Table 1 Univariate analysis of diet and melatonin use and its duration

	Liver weight (g)	P value	Liver weight/body weight (%)	P value	Portal vein pressure (mmHg)	P value
Diet
HFD	13.3 ± 2.8	< 0.001	3.5 ± 0.5	< 0.001	11.9 ± 2.7	< 0.001
RD	9.1 ± 1.3	BV	2.4 ± 0.3	BV	8.0 ± 1.7	BV
Melatonin
10 mg/kg	11.2 ± 2.5	< 0.001	3.0 ± 0.5	< 0.001	10.5 ± 2.6	0.01
5 mg/kg	11.3 ± 2.3	< 0.001	3.0 ± 0.6	< 0.001	10.3 ± 2.8	0.03
0 mg/kg	16.2 ± 2.3	BV	4.0 ± 0.5	BV	13.0 ± 3.5	BV
Duration
8 wk	12.0 ± 3.6	0.86	3.2 ± 0.7	0.71	10.1 ± 2.5	0.02
4 wk	12.2 ± 2.6	BV	3.2 ± 0.7	BV	12.0 ± 3.3	BV

Variables are expressed as mean ± SD. HFD: High fat diet; RD: Regular diet; BV: Baseline value.