Lymphocyte subsets in alcoholic liver disease

Table 3 Clinical and laboratory comparison between alcoholic liver disease cases with active alcoholism vs controls with no cirrhosis

	Patients (n = 26)	Controls (n = 27)	P value
Age (yr)	44.4 ± 14.4	47.4 ± 14.4
Men (%)	88.5	14.8	<0.0001
WBC (× 109/L)	6.9 ± 1.8	6.1 ± 1.4	NS
Neutrophils (× 109/L)	4.3 ± 1.5	3.4 ± 1.2	0.011
RBC (× 1012/L)	4.1 ± 0.7	4.5 ± 0.4	NS
Hemoglobin (g/L)	14.0 ± 4.0	13.9 ± 1.2	NS
MCV (fL)	99.9 ± 5.9	90.8 ± 4.0	<0.0001
Platelets (× 109/L)	204.7 ± 84.6	231.0 ± 36.0	NS
INR	1.1 ± 0.2	1.0 ± 0.1	NS
Creatinin (mg/dL	0.9 ± 0.2	0.8 ± 0.1	NS
Albumin (g/dL)	4.0 ± 0.5	3.9 ± 0.6	NS
Albumin/globulin ratio	1.4 ± 0.3	1.4 ± 0.3	NS
Alkaline phosphatase (UI/dL)	102.3 ± 74.1	68.3 ± 14.0	NS
GGT (UI/dL)	297.8 ± 33.1	37.9 ± 33.1	<0.0001
ALT (UI/dL)	55.8 ± 41.6	29.4 ± 15.3	<0.0001
AST (UI/dL)	72.2 ± 52.8	25.1 ± 7.9	<0.0001
Total bilirubin (mg/dL)	1.1 ± 0.6	0.7 ± 0.3	0.027
CRP (mg/dL)	1.1 ± 2.0	0.7 ± 0.7	NS
Lymphocyte Subsets
Lymphocytes (× 109/L)	1.8 ± 0.3	2.1 ± 0.5	0.018
CD3+ lymphocytes (/mm3)	1164.7 ± 376.6	1523.0 ± 364.6	0.001
CD4+ lymphocytes (/mm3)	759.8 ± 265.0	992.4 ± 274.7	0.003
CD8+ lymphocytes (/mm3)	330.9 ± 156.3	478.9 ± 164.6	0.002
CD4+/CD8+ ratio	2.5 ± 1.1	2.3 ± 0.9	NS
CD19+ lymphocytes (/mm3)	107.8 ± 64.2	264.6 ± 88.0	<0.0001
NK lymphocytes (/mm3)	180.2 ± 169.0	178.7 ± 210.0	NS

WBC: White blood cell; RBC: Right blood cell; MCV: Mean cell volume; INR: International normalized ratio; GGT: γ-glutamyl transpeptidase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; CRP: C-reactive protein; NK: Natural killer; NS: Not significant.