Identification of cellular genes showing differential expression associated with hepatitis B virus infection

Table 2 Representative genes in enriched functional categories

Category	No. of genes	P value1	Genes	Accession number2
Up regulated
Lipid synthesis	3	0.01	3-hydroxy-3-methylglutaryl-coenzyme A reductase	NM_000859
			7-dehydrocholesterol reductase	NM_001360
			Growth differentiation factor 1	M62302
Glycoprotein	15	0.019	Integrin beta 3	NM_000212
			Interleukin 1 alpha	NM_000575
			Vitronectin	NM_000638
Biopolymer metabolism	16	0.02	Cell division cycle 7	NM_003503
			Colony stimulating factor 1 receptor	NM_005211
			Connective tissue growth factor	NM_001901
Hydrolase activity	6	0.046	Bile acid coenzyme A: amino acid n-acyltransferase	NM_001701
			Inositol polyphoshpate-5-phosphatase	AF184215
			Poly(A)-specific ribonuclease	AJ005698
Down regulated
Signal	17	0.001	Cytotoxic T-lymphocyte-associated protein 4	NM_005214
			Epithelial cell adhesion molecule	NM_002354
			Gamma-aminobutyric acid A receptor alpha 4	NM_000809
Protease Inhibitor	3	0.024	Cystatin A	BC010379
			Secretory leukocyte peptidase inhibitor	NM_003064
			Tissue factor pathway inhibitor	AF021834
Sensory perception	3	0.024	Collagen type I alpha 2	NM_000089
			GATA binding protein 3	BC006839
			USHER syndrome 1C	NM_005709
Transport	7	0.031	Amyloid beta precursor protein binding family A member 2	BC007794
			ATP-binding cassette subfamily D member 4	NM_020323
			Solute carrier family 17 member 2	AL138726
Cytokine activity	4	0.046	Chemokine ligand 25	AB046579
			Kit ligand	NM_000899
			Prolactin	NM_000948

¹Probability of gene enrichment calculated using Fisher’s exact test by referencing the frequency in 30 000 genes of human genome background;

²GenBank accession number.