Insulin resistance and chronic liver disease

Figure 1 Scheme for HCV genotype difference in the molecular pathogenesis of insulin resistance and hepatocarcinogenesis. HCV: Hepatitis C virus; STAT: Signal transducer and activator of transcription; SOCS: Suppressor of cytokine signaling; mTOR: Mammalian target of rapamycin; PPAR: Peroxisome proliferator-activated receptor; IGFBP: Insulin-like growth factor binding protein; IGF: Insulin-like growth factor; IRS: Insulin receptor substrate; MAPK: Mitogen-activated protein kinase.