Asymptomatic primary biliary cirrhosis is not associated with increased frequency of cardiovascular disease

Table 1 Baseline characteristics of patients with primary biliary cirrhosis and controls

Variables	Controls	PBC	P value
	n = 151	n = 180
Age (years)	49.8 (20-72)	56.3 (22-74)	< 0.001
Female gender	65 (43)	165 (91.7)	< 0.001
Caucasian	123 (81.5)	158 (87.8)	0.1
AMA	0 (0)	137 (77.8)
BMI (kg/m2)	28 (17-50)	26.8 (17.6-51)	0.09
Hypertension	49 (32.5)	48 (26.8)	0.3
Diabetes	21 (13.9)	26 (14.5)	0.9
Smoking	96 (63.6)	62 (35)	< 0.001
Stage of diseasea			0.001
0-2	28 (21.1)	64 (38.6)
3-4	105 (78.9)	102 (61.4)
Total cholesterol (mg/dL)	157.5 (73-320)	216 (81-2055)	< 0.001
LDL (mg/dL)	80 (20-189)	127 (12–539)	< 0.001
HDL (mg/dL)	48 (20-101)	54 (17-163)	0.001
Triglyceride (mg/dL)	117 (19-2334)	104 (32-736)	0.2
Statin use	2 (1.3)	15 (8.3)	0.004
CAD	8 (5.3)	14 (7.8)	0.4
TIA	2 (1.3)	1 (0.6)	0.6
Stroke	0 (0)	3 (1.7)	0.3
Any CVD	10 (6.6)	18 (10)	0.3

PBC: primary biliary cirrhosis; AMA: antimitochondrial antibody; BMI: body mass index; LDL: low density lipoprotein; HDL: high density lipoprotein; CAD: coronary artery disease; TIA: transient ischemic attack; CVD: cardiovascular disease. Continuous variables are expressed as median (range). Categorical variables are expressed as number (frequency).

^aBased on the Metavir scoring system