Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients

Table 1 The associations between PD-1 genotype and chronic HBV infection by family-based association test

Marker	Genotype	Frequency	Familya	S	E(S)	Var(S)	Zb	P
PD-1.1	A/A	0.166	46	30	29.311	12.718	0.193	0.847
	A/G	0.637	72	47	49.794	20.122	-0.623	0.533
	G/G	0.197	42	30	27.895	11.630	0.617	0.537
PD-1.2	A/A	0.228	53	38	34.228	14.206	1.001	0.317
	A/G	0.598	78	50	54.044	21.696	-0.868	0.385
	G/G	0.174	41	27	26.728	11.593	0.080	0.936

^aNumber of nuclear families informative for that allele; S is the test statistic; E(S) and Var(S) are the expected value and variance of the test statistic, respectively; ^bThe negative sign of Z statistic indicates that the frequency of transmitted genotype is negative association with susceptibility of chronic HBV infection. PD-1: pro­grammed death-1; HBV: hepatitis B virus.