Cellular fibronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury

Figure 1 Ethanol administration delays degradation of iodinated cellular fibronectin in rats. Isolated hepatocytes were obtained from rats fed a control or ethanol-containing liquid diet for 4-6 wk. The degradation of iodinated cellular fibronectin (¹²⁵I-cFn) that has been internalized by the hepatocytes was monitored over a 3-h time period as described in Material and Methods. Data are presented as femtomoles bound per μg DNA and are means ± SEM (n = 3 experiments).