Review
Copyright ©2010 Baishideng.
World J Hepatol. Mar 27, 2010; 2(3): 114-126
Published online Mar 27, 2010. doi: 10.4254/wjh.v2.i3.114
Figure 1
Figure 1 The liver cancer initiation hypothesis based on CSCs theory. The hepatic stem cells (SC) and oval progenitor (OC) cells have specific capacities to self renew and differentiate into multiple hepatic lineages. Mutations in SC and/or OC may modify the cells genetic property and switch the normal SC into CSCs leading to tumor initiation.