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©2010 Baishideng.
World J Hepatol. Mar 27, 2010; 2(3): 114-126
Published online Mar 27, 2010. doi: 10.4254/wjh.v2.i3.114
Published online Mar 27, 2010. doi: 10.4254/wjh.v2.i3.114
Table 1 Human ABC transporter genes and proteins conferred drug resistance
| Official symbol | Alternative name | Members | Proteins associated with drug resistance | Resistant drugs |
| ABCA | 13 (ABCA1 to ABCA13) | ABCA2 | Mitoxantrone | |
| ABCB | MDR | 11 (ABCB1 to ABCB11) | ABCB1 (MDR1/PGP) | Doxorubicin, colchicine, etoposide, paclitaxel, cisplatin, methotrexate, daunorubicin, camptothecin |
| ABCB11 (BSEP) | 5-fluorouracil, paclitaxel | |||
| ABCC | MRP | 13 (ABCC1 to ABCC13) | ABCC1 (MRP1) | Doxorubicin, daunorubicin, methotrexate, colchicine |
| ABCC2 (MRP2) | Doxorubicin, cisplatin, etoposide | |||
| ABCC3 (MRP3) | Methotrexate, etoposide | |||
| ABCC6 (MRP6) | Etoposide | |||
| ABCC10 (MRP7) | Vinorelbine, paclitaxel, docetaxel | |||
| ABCC11 (MRP8) | 5-fluorouracil, tamoxifen, paclitaxel | |||
| ABCD | ALD | 4 (ABCD1 to ABCD4) | ||
| ABCE | OABP | 1 (ABCE1) | ||
| ABCF | GCN20 | 3 (ABCF1 to ABCF3) | ||
| ABCG | White | 5 (ABCG1, ABCG2, ABCG4, ABCG5, ABCG8) | ABCG2 (BCRP) | Mitoxantrone, topotecan, doxorubicin, daunorubicin, cisplatin, etoposide |
- Citation: Sukowati CH, Rosso N, Crocè LS, Tiribelli C. Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma. World J Hepatol 2010; 2(3): 114-126
- URL: https://www.wjgnet.com/1948-5182/full/v2/i3/114.htm
- DOI: https://dx.doi.org/10.4254/wjh.v2.i3.114