From virological selection to immune stratification: Hepatitis B virus-specific T cells for precision pegylated interferon therapy in chronic hepatitis B

doi:10.4254/wjh.124884

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Sep 27, 2026; 18(9): 124884
Published online Sep 27, 2026. doi: 10.4254/wjh.124884

Table 1 Classification, biological significance, predictive performance, and clinical accessibility of biomarkers for predicting pegylated interferon therapeutic response in chronic hepatitis B

Biomarker category	Representative markers	Biological significance	Predictive value score (1-5)	Clinical feasibility score (1-5)
Virological markers	HBsAg, HBcrAg	Antigen burden	4	5
Exhaustion markers	PD-1, TOX, CD160	Degree of T cell exhaustion	3	2
Recovery-potential markers	TCF-1, CD127, Bcl-2	Tpex cell reservoir reserve	5	2
Functional markers	IFN-γ, TNF-α	Actual effector functionality	4	1
Composite score	Exhaustion index	Comprehensive immune status	5	3

HBsAg: Hepatitis B surface antigen; HBcrAg: Hepatitis B core-related antigen; PD-1: Programmed cell death protein 1; TOX: Thymocyte selection-associated high mobility group box protein; CD160: Cluster of differentiation 160; TCF-1: T cell factor 1; CD127: Interleukin-7 receptor alpha; Bcl-2: B-cell lymphoma-2; Tpex: Progenitor exhausted T; IFN-γ: Interferon-gamma; TNF-α: Tumor necrosis factor-alpha.

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Citation: Tian B, Tian C, Shen CL, Zhang Q. From virological selection to immune stratification: Hepatitis B virus-specific T cells for precision pegylated interferon therapy in chronic hepatitis B. World J Hepatol 2026; 18(9): 124884
URL: https://www.wjgnet.com/1948-5182/full/v18/i9/124884.htm
DOI: https://dx.doi.org/10.4254/wjh.124884

Tian B, Tian C, Shen CL, Zhang Q. From virological selection to immune stratification: Hepatitis B virus-specific T cells for precision pegylated interferon therapy in chronic hepatitis B. World J Hepatol 2026; 18(9): 124884 [DOI: 10.4254/wjh.124884]

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