Splenic stiffness measurement to predict decompensation in compensated advanced chronic liver disease

Table 1 Baseline parameters of patients with compensated advanced chronic liver disease of different etiology, n (%)/mean ± SD

Parameters	Overall (n = 231)	MASLD (n = 52)	ArLD (n = 43)	HCV (n = 75)	HBV (n = 60)
Age (years)	45.18 ± 9.73	47 ± 10.7	39.09 ± 7.17	47 ± 8.88	44 ± 9.33
Male:female	96:135	22:31	42:1	14: 61	18:42
Hemoglobin	11.66 ± 1.87	11.53 ± 1.75	11.82 ± 1.76	11.92 ± 1.95	11.37 ± 1.94
Total leukocyte count	5077.0 ± 1622	4857 ± 1436	5154 ± 1454	5322 ±1837	4905 ± 1582
Platelet	1.1 ± 0.43	1.49 ± 0.49	1.14 ± 0.47	1.43 ± 0.49	1.08 ±0.41
Total bilirubin	1.01 ± 0.54	1.6 ± 0.56	0.92 ± 0.67	1.0 ± 0.46	1.11 ± 0.55
Conjugated bilirubin	0.61 ± 0.33	0.7 ± 0.31	0.50 ± 0.33	0.62 ± 0.21	0.64 ± .13
AST	64 ± 30	63 ± 23	71 ± 37	70 ± 33	54.20 ± 21
ALT	49.18 ± 26	48 ± 20	56 ± 37	52 ± 29.5	40.8 ± 16
ALP	117 ± 43	121 ± 56	127 ± 36	121.6 ± 38	127 ± 34
Albumin	4.10 ± 2.6	3.87 ± 0.41	3.84 ± 0.50	3.82 ± 1.38	4.4 ± 2.76
Protein	8.8 ± 5.3	8.7 ± 3.1	8.45 ± 2.47	7.74 ± 0.61	8.1 ± 3.23
INR	1.12 ± 0.19	1.14 ± 0.20	1.09 ± 0.21	1.11 ± 0.16	1.15 ± 0.20
Urea	28.8 ± 9.27	31 ± 10.3	24.5 ± 8.75	28.42 ± 7.96	29.8 ± 9.21
Creatinine	0.88 ± 0.19	0.89 ± 0.19	0.50 ± 0.33	0.86 ± 0.19	0.89 ± 0.18
LSM	23.5 ± 7.9	23 ± 7.3	21.9 ± 8.17	24.5 ± 8.06	23.7 ± 8.12
SSM	46.4 ± 16.8	47.26 ± 16.47	47.26 ± 17.9	45.6 ± 15.9	49.9 ± 17.42
FIB-4	4.45 ± 2.5	4.78 ± 2.63	3.88 ± 2.34	4.90 ± 2.80	4.03 ± 2.11
APRI	1.73 ± 1.14	1.76 ± 1.02	1.89 ± 1.29	1.49 ± 0.94	1.83 ± 1.26
Decompensation	19 (8.22)	7 (13.4)	5 (11.62)	4 (5.3)	3 (5)
Death	5 (2.17)	2 (3.8)	2 (4.6)	0	1 (1.6)

ArLD: Alcohol related liver disease; HCV: Hepatitis C virus; HBV: Hepatitis B virus; MASLD: Metabolic dysfunction-associated steatotic liver disease; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; INR: International normalized ratio; SSM: Splenic stiffness measurement; LSM: Liver stiffness measurement; FIB-4: Fibrosis-4 index; APRI: Aspartate aminotransferase to platelet ratio index.