Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats

Table 1 Rat liver tissue histopathological findings, mean ± SEM

	Group C (n = 6)	Group IRI (n = 6)	Group IRI-F (n = 6)	Group IRI-D (n = 6)	Group IRI-F-D (n = 6)	P value1
Hepatocyte degeneration	0.33 ± 0.21	1.67 ± 0.21a	0.67 ± 0.21b	1.00 ± 0.26a,b	0.67 ± 0.21b	0.003
Sinusoidal dilation	0.50 ± 0.22	1.83 ± 0.31a	0.83 ± 0.17b	1.17 ± 0.31	1.00 ± 0.26b	0.018
Pyknotic nuclei	0.33 ± 0.21	1.33 ± 0.21a	0.50 ± 0.22b	0.67 ± 0.21b	0.67 ± 0.21b	0.031
Cells undergoing necrosis	0.33 ± 0.21	1.00 ± 0.00	0.50 ± 0.22	0.83 ± 0.31	0.67 ± 0.21	0.113
Parenchymal mononuclear cell infiltration	0.17 ± 0.17	1.67 ± 0.33a	0.67 ± 0.21b	1.00 ± 0.26a	0.67 ± 0.21b	0.003

^aP < 0.05 vs control group.

^bP < 0.05 vs ischemia-reperfusion injury group.

¹Determined by Kruskal-Wallis test.

C: Control; IRI: Ischemia-reperfusion injury; IRI-F: Ischemia-reperfusion injury + fullerenol C60; IRI-D: Ischemia-reperfusion injury + desflurane; IRI-F-D: Ischemia-reperfusion injury + fullerenol C60 + desflurane.