Maternal hepatitis E virus infection: Immunopathogenesis, genotype-specific severity, and vertical transmission dynamics

doi:10.4254/wjh.122717

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Sep 27, 2026; 18(9): 122717
Published online Sep 27, 2026. doi: 10.4254/wjh.122717

Table 3 Simplified differential diagnosis of hepatitis E virus infection in pregnancy

If the patient has etc.	Most likely diagnosis
Viral prodrome + positive HEV RNA/IgM	HEV infection
Hypertension/proteinuria + thrombocytopenia + hemolysis	HELLP syndrome
Hypoglycemia + hyperammonemia + severe coagulopathy	Acute fatty liver of pregnancy
Severe pruritus + elevated bile acids	Intrahepatic cholestasis of pregnancy

HEV: Hepatitis E virus; IgM: Immunoglobulin M; HELLP: Hemolysis, elevated liver enzymes and low platelets count.

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Citation: Sharma K, Pandey MK, Singh AK, Sikenis M, Prajapati B, Jothish A, Bhukya PL, Vyas AK, Simovic Markovic BJ, Corovic IF, Nema RK. Maternal hepatitis E virus infection: Immunopathogenesis, genotype-specific severity, and vertical transmission dynamics. World J Hepatol 2026; 18(9): 122717
URL: https://www.wjgnet.com/1948-5182/full/v18/i9/122717.htm
DOI: https://dx.doi.org/10.4254/wjh.122717

Sharma K, Pandey MK, Singh AK, Sikenis M, Prajapati B, Jothish A, Bhukya PL, Vyas AK, Simovic Markovic BJ, Corovic IF, Nema RK. Maternal hepatitis E virus infection: Immunopathogenesis, genotype-specific severity, and vertical transmission dynamics. World J Hepatol 2026; 18(9): 122717 [DOI: 10.4254/wjh.122717]

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