Acute hepatitis B in the vaccination era: Predictors of functional cure and chronicity

Table 2 Clinical presentation of patients with chronic hepatitis B virus and patients who achieved functional cure, n (%) or mean ± SD

	Total (n = 78)	Chronic HBV (n = 27)	Functional cure (n = 51)	P value1
ALT (IU/mL)	1770 ± 1585	1103 ± 1540	2117 ± 1509	0.01
AST (IU/mL)	1193 ± 1111	838 ± 1166	1378 ± 1046	0.058
Total bilirubin (mg/dL)	10.2 ± 8.87	6.52 ± 8.62	12.0 ± 8.5	0.01
Direct bilirubin (mg/dL)	4.31 ± 3.98	4.26 ± 5.89	6.87 ± 4.99	0.07
Alkaline phosphatase (IU/mL)	190 ± 101	159 ± 87	207 ± 105	0.04
GGT (IU/mL)	219 ± 144	175 ± 128	236 ± 148	0.12
Albumin (g/dL)	3.78 ± 0.57	3.86 ± 0.54	3.74 ± 0.59	0.4
INR	1.39 ± 0.85	1.24 ± 0.42	1.46 ± 1.0	0.2
Creatinine (mg/dL)	0.81 ± 0.31	0.89 ± 0.43	0.77 ± 0.23	0.2
Hemoglobin (g/dL)	13.78 ± 1.88	14.26 ± 1.82	13.53 ± 1.89	0.1
Platelets (× 103/micL)	230 ± 99	216 ± 121	238 ± 85	0.4
Na (mEq/L)	138.5 ± 3.0	138.7 ± 3.1	138.4 ± 2.9	0.7
MELD-3	8.97 ± 3.16	8.19 ± 3.07	9.34 ± 3.17	0.2
NA treatment				0.4
Entecavir	6 (7.6)	2 (7.4)	4 (7.8)
Lamivudine	1 (1)	1 (3.4)	0 (0)
No treatment	71 (91)	24 (89)	47 (92)

¹Welch two sample t-test.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma glutamyl transferase; INR: International normalized ratio; NA: Nucleos(t)ide analogue; HBV: Hepatitis B virus.