Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis

doi:10.4254/wjh.122262

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Aug 27, 2026; 18(8): 122262
Published online Aug 27, 2026. doi: 10.4254/wjh.122262

Table 1 Details of the herbs in the Jianpi Huoxue Formula

Chinese name	Latin name	Part(s) used	Amount (g)	Source (manufacturer)	Batch number	Processing specification (per ChP 2020)
Renshen	Panax Ginseng C. A. Mey.	Roots and rhizomesroots	10	Anguo Kangtai Pharmaceutical Co., Ltd.	20230115	Unprocessed (selected for intact roots, no insect damage)
Fulin	Poria Cocos (Schw.) Wolf.	Sclerotium	10	Anhui Huayuan Chinese Herbal Pieces Co., Ltd.	20230208	Decorticated (removed outer bark, cut into 1-2 cm thick slices)
Baizhu	Atractylodes Macrocephala Koidz.	Roots and rhizomesroots	10	Bozhou Huichuntang Chinese Herbal Pieces Co., Ltd.	20230312	Stir-fried (stir-fried with wheat bran until slightly yellow, to enhance spleen-invigorating effect)
Gancao	licorice	Roots and rhizomesroots	10	Ningxia Qiyuan Chinese Herbal Pieces Co., Ltd.	20230120	Honey-roasted (stir-fried with mature honey until evenly coated, to strengthen qi-tonifying effect)
Danggui	Angelicae Sinensis Radix	Roots	10	Gansu Minxian Zhongtian Pharmaceutical Co., Ltd.	20230225	Unprocessed (cut into 2-4 mm thin slices, with strong aromatic odor)
Chuanxiong	Chuanxiong Rhizoma	Roots and rhizomesroots	10	Sichuan Chuanxiong Pharmaceutical Co., Ltd.	20230305	Unprocessed (cut into irregular thin slices, brownish-yellow cross-section)
Baishao	Paeoniae Radix Alba	Roots	10	Anhui Bozhou Baicao Chinese Herbal Pieces Co., Ltd.	20230130	Boiled (boiled in water until the cross-section is white, peeled, cut into slices, dried; raw Baishao, to nourish blood and soothe liver)
Shudihuang	Rehmanniae Radix Praeparata	Roots	10	Henan Huaiqing Pharmaceutical Co., Ltd.	20230218	Steamed (steamed with rice wine, then sun-dried repeatedly until black and glossy, to tonify kidney-yin)
Taoren	Persicae Semen	Seed	10	Shaanxi Weinan Chinese Herbal Pieces Co., Ltd.	20230320	Blanched (blanched in boiling water to remove seed coat, dried, crushed slightly)
Honghua	Carthami Flos	Flower	10	Xinjiang Hotan Red Flower Co., Ltd.	20230205	Unprocessed (selected for bright red florets, no impurities)

Full Size Table

Citation: Huang L, Wu CG, Zhu TF, Li QL, Yu QS, Zhang Q, Shen Y. Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis. World J Hepatol 2026; 18(8): 122262
URL: https://www.wjgnet.com/1948-5182/full/v18/i8/122262.htm
DOI: https://dx.doi.org/10.4254/wjh.122262

Huang L, Wu CG, Zhu TF, Li QL, Yu QS, Zhang Q, Shen Y. Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis. World J Hepatol 2026; 18(8): 122262 [DOI: 10.4254/wjh.122262]

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