Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation

doi:10.4254/wjh.118194

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 8

This Article

(3)

(2)

(0)

(14)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Opinion Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Aug 27, 2026; 18(8): 118194
Published online Aug 27, 2026. doi: 10.4254/wjh.118194

Full Size Figure Download Figure

Figure 1 Mechanistic framework of NR1D1-centered chrono-metabolic regulation in hepatic fibrosis. NR1D1 acts as a central circadian-metabolic node, inhibiting HIF-1α signaling and reducing ammonia-induced hepatic stellate cell activation, thereby mitigating fibrogenesis. Pharmacological and natural compounds (e.g., Hedyotis diffusa, ferulic acid, and dihydroartemisinin) restore NR1D1 expression and downstream pathways. Additional modulatory nodes, including bile acid signaling, non-coding RNAs (MALAT1 and lnc-LFAR1), and PPARα-mediated inflammasome regulation, further refine temporal and metabolic control. HSC: Hepatic stellate cell; ECM: Extracellular matrix.

Citation: Tu HS, Chen ML, Hong J, He L. Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation. World J Hepatol 2026; 18(8): 118194
URL: https://www.wjgnet.com/1948-5182/full/v18/i8/118194.htm
DOI: https://dx.doi.org/10.4254/wjh.118194

Tu HS, Chen ML, Hong J, He L. Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation. World J Hepatol 2026; 18(8): 118194 [DOI: 10.4254/wjh.118194]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.