Poria in Fuling Zexie decoction for treating metabolic dysfunction-associated steatotic liver disease: Underlying mechanisms and key bioactive substances

Figure 1 Efficacy of Fuling Zexie decoction/Fuling Zexie decoction without Poria/Fuling Zexie decoction supplemented with Poria dregs against metabolic dysfunction-associated steatotic liver disease. A: Body weigh; B: Average food intake; C: Liver index; D: Liver weight; E: Serum total cholesterol; F: Serum triglyceride; G: Serum low-density lipoprotein cholesterol; H: Serum aspartate transaminase; I: Serum alanine transaminase; J: Serum interleukin-6; K: Serum high-density lipoprotein cholesterol; L: Serum tumor necrosis factor-α; M: Liver total cholesterol; N: Liver triglyceride; O: Liver alanine transaminase; P: Liver aspartate transaminase; Q: Liver interleukin-6; R: Liver interleukin-1β; S: Liver superoxide dismutase; T: Liver malondialdehyde; U: Hematoxylin-eosin staining sections (scale bar = 50 μm); V: Oil red O staining sections (scale bar = 50 μm); W: Masson trichrome staining sections (scale bar = 50 μm). n = 6, and the results are expressed as mean ± SD. ^aP < 0.05 vs the high-fat diet group, ^bP < 0.01 vs the high-fat diet group, ^cP < 0.001 vs the high-fat diet group, ^dP < 0.0001 vs the high-fat diet group. NC: Normal control; HFD: High-fat diet; FC: Fenofibrate capsules; LFZD: Low-dose Fuling Zexie decoction; HFZD: High-dose Fuling Zexie decoction; LZD: Low-dose Fuling Zexie decoction without Poria; HZD: High-dose Fuling Zexie decoction without Poria; LFFZD: Low-dose Fuling Zexie decoction supplemented with Poria dregs; HFFZD: High-dose Fuling Zexie decoction supplemented with Poria dregs; TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; AST: Aspartate transaminase; ALT: Alanine transaminase; IL: Interleukin; HDL-C: High-density lipoprotein cholesterol; TNF: Tumor necrosis factor.