Poria in Fuling Zexie decoction for treating metabolic dysfunction-associated steatotic liver disease: Underlying mechanisms and key bioactive substances

doi:10.4254/wjh.121954

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jul 27, 2026; 18(7): 121954
Published online Jul 27, 2026. doi: 10.4254/wjh.121954

Table 1 The pathway regulated by Fuling Zexie decoction/Fuling Zexie decoction without Poria

No	Pathway name	Match status	Compound
1	Biotin metabolism¹	1/10	FZD
2	Riboflavin metabolism	1/4	FZD/ZD
3	Ascorbate and aldarate metabolism¹	1/9	FZD
4	Starch and sucrose metabolism	1/18	FZD/ZD
5	Alanine, aspartate and glutamate metabolism¹	1/28	FZD
6	Inositol phosphate metabolism¹	2/30	FZD
7	Galactose metabolism¹	2/27	FZD
8	Primary bile acid biosynthesis	2/39	FZD/ZD
9	Pyrimidine metabolism	2/32	FZD/ZD
10	Glyoxylate and dicarboxylate metabolism	2/30	FZD/ZD
11	Lysine degradation	2/30	FZD/ZD
12	Arginine and proline metabolism	2/36	FZD/ZD
13	Neomycin, kanamycin and gentamicin biosynthesis	1/20	FZD/ZD
14	Arginine biosynthesis	1/14	ZD
15	Porphyrin metabolism	1/36	ZD
16	Arachidonic acid metabolism	2/44	ZD

¹The pathways exclusively-regulated by Fuling Zexie decoction.

FZD: Fuling Zexie decoction; ZD: Fuling Zexie decoction without Poria.

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Citation: Tao YX, Gong DH, Yang H, Wang PQ, Tang YM, Zhou QD, Wang YY, Zhang Y, Chen WD, Yu J, Yang XX. Poria in Fuling Zexie decoction for treating metabolic dysfunction-associated steatotic liver disease: Underlying mechanisms and key bioactive substances. World J Hepatol 2026; 18(7): 121954
URL: https://www.wjgnet.com/1948-5182/full/v18/i7/121954.htm
DOI: https://dx.doi.org/10.4254/wjh.121954

Tao YX, Gong DH, Yang H, Wang PQ, Tang YM, Zhou QD, Wang YY, Zhang Y, Chen WD, Yu J, Yang XX. Poria in Fuling Zexie decoction for treating metabolic dysfunction-associated steatotic liver disease: Underlying mechanisms and key bioactive substances. World J Hepatol 2026; 18(7): 121954 [DOI: 10.4254/wjh.121954]

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