Clinicopathological characteristics and risk factors in nonalcoholic steatohepatitis patients with different stages of liver fibrosis

doi:10.4254/wjh.121661

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jul 27, 2026; 18(7): 121661
Published online Jul 27, 2026. doi: 10.4254/wjh.121661

Table 3 Comparison of laboratory test results

Variable	Total (n = 122)	Stage F1 (n = 21)	Stage F2 (n = 86)	Stage F3 (n = 15)	P value
ALT (U/L)	85 (53.4, 141.7)	70.2 (39, 121)	85.5 (55.7, 143.5)	93.2 (59, 158.3)	0.351
AST (U/L)	49.5 (36.2, 76)	47 (29.1, 66.9)^a	49 (36.2, 71.5)	80 (43.9, 100.4)	0.031
ALP (U/L)	76.1 (63, 89.3)	71(58, 89.6)	77.3 (63.9, 88)	86 (54.9, 98.4)	0.498
GGT (U/L)	70.4 (46.8, 105.2)	72 (39, 115.2)	70.4 (46, 106.1)	70 (58, 97.5)	0.9
ALB (g/L)	47.6 (45.5, 49.8)	47.5 (44.7, 49)	47.8 (46, 50.3)^b	45.5 (42.2, 47.9)	0.008
TBA (µmol/L)	3.2 (2, 5.3)	3 (2, 6)	3 (2, 5)	4 (3, 6)	0.367
TP (g/L)	75.5 ± 5.1	75.2 ± 5.9	75.9 ± 4.7	73.2 ± 5.9	0.163
TBIL (µmol/L)	14 (11.6, 17.4)	14 (10.5, 18.7)	13.4 (11.5, 17.2)	15.2 (13.1, 18.8)	0.241
DBIL (µmol/L)	2.9 (1.9, 4.5)	2.4 (1.7, 6.2)	3 (1.7, 4.4)	2.4 (1.9, 4.7)	0.972
IBIL (μmol/L)	11 (8.8, 13.2)	11.1 (7.6, 14.2)	10.8 (8.8, 12.5)	12.8 (10, 13.5)	0.251
BUN (g/L)	4.5 (3.9, 5.2)	6.6 (3.9, 5)	4.5 (3.8, 5.2)	4.9 (4.2, 5.9)	0.195
CRE (µmol/L)	62.9 ± 14.4	62.6 ± 13.8	62.6 ± 14.0	65.5 ± 18.3	0.766
UA (µmol/L)	375 (334.4, 466)	379 (346.8, 490.5)	375 (320.9, 462.6)	374 (363, 491)	0.646
eGFR (mL/minute/1.73 m²)	110.8 ± 13.7	110.6 ± 14.3	113.3 ± 12.1^c	102.5 ± 18.6	0.036
FPG (mmol/L)	5.9 (5.5, 6.7)	5.7 (5.4, 6.2)	6 (5.5, 6.8)	6.2 (5.3, 6.9)	0.169
TC (mmol/L)	5.4 ± 1.2	5.2 ± 1.3	5.4 ± 1.2	6.0 ± 1.3	0.159
TG (mmol/L)	1.8 (1.4, 2.5)	1.9 (1.7, 3)	1.8 (1.3, 2.4)	1.9 (1.5, 2.5)	0.231
HDL (mmol/L)	1.3 ± 0.3	1.3 ± 0.3	1.3 ± 0.3	1.3 ± 0.2	0.599
LDL (mmol/L)	3.3 ± 1	2.9 ± 0.9^d	3.3 ± 0.9	3.8 ± 1	0.034
Glo (%)	15.3 (13.8, 16.8)	15.7 (13.8, 16.5)	15.1 (13.9, 17.1)	15.2 (12.8, 17.4)	0.942
IgG (g/L)	11.95 (10.31, 14.14)	11.8 (9.44, 14.07)	12.33 (10.68, 14.28)	11.2 (10, 13.45)	0.29
IgM (g/L)	0.95 (0.69, 1.19)	0.97 (0.73, 1.18)	0.9 (0.66, 1.17)	1.13 (0.73, 1.72)	0.267
IgA (g/L)	2.43 (1.81, 3.21)	2.32 (1.83, 3.11)	2.5 (1.82, 3.18)	2.23 (1.54, 3.49)	0.949
WBC (10⁹/L)	6.3 ± 1.5	6.3 ± 1.6	6.3 ± 1.5	6.5 ± 1.2	0.856
RBC (10¹²/L)	4.91 (4.59, 5.29)	4.84 (4.47, 5.12)	4.95 (4.59, 5.36)	4.88 (4.56, 5.29)	0.351
Hb (g/L)	146 ± 14.6	144 ± 10.7	146.9 ± 15.7	145.9 ± 12.4	0.72
PLT (10⁹/L)	248 ± 65	247.6 ± 78.6	252.2 ± 66.0	224.7 ± 31.1	0.309
PT (s)	11.1 (10.6, 12.53)	12.1 (10.4, 12.95)	11.1 (10.6, 11.95)	11.6 (10.8, 13)	0.272

^aP = 0.03 vs stage F3 group.

^bP = 0.002 vs stage F3 group.

^cP = 0.03 vs stage F3 group.

^dP = 0.031 vs stage F3 group.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; ALB: Albumin; TBA: Total bile acids; TP: Total protein; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; BUN: Blood urea nitrogen; CRE: Creatinine; UA: Uric acid; eGFR: Estimated glomerular filtration rate; FPG: Fasting plasma glucose; TC: Total cholesterol; TG: Triglycerides; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; Glo: Globulin; IgG: Immunoglobulin G; IgM: Immunoglobulin M; IgA: Immunoglobulin A; WBC: White blood cell; RBC: Red blood cell; Hb: Hemoglobin; PLT: Platelets; PT: Prothrombin time.

Full Size Table

Citation: Pan PY, Zheng WW, Guo YQ, Liu YG, Zhang XJ, Wu YY, Li JZ, Qi JG, Wang CY. Clinicopathological characteristics and risk factors in nonalcoholic steatohepatitis patients with different stages of liver fibrosis. World J Hepatol 2026; 18(7): 121661
URL: https://www.wjgnet.com/1948-5182/full/v18/i7/121661.htm
DOI: https://dx.doi.org/10.4254/wjh.121661

Pan PY, Zheng WW, Guo YQ, Liu YG, Zhang XJ, Wu YY, Li JZ, Qi JG, Wang CY. Clinicopathological characteristics and risk factors in nonalcoholic steatohepatitis patients with different stages of liver fibrosis. World J Hepatol 2026; 18(7): 121661 [DOI: 10.4254/wjh.121661]

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