Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction

doi:10.4254/wjh.121423

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jul 27, 2026; 18(7): 121423
Published online Jul 27, 2026. doi: 10.4254/wjh.121423

Table 3 Dynamic stimulator of interferon genes immunofluorescence intensity during metabolic dysfunction-associated fatty liver disease malignancy

Group	n	Hepatic STING fluorescence intensity
Group	n	-	+	++	+++
NC	12	12	0	0	0
MAFLD	12	6	6	0	0
MASH	17	0	13	4	0
LC	15	0	5	9	1
HCC	10	0	0	1	9

P < 0.001, H = 62.991. NC: Normal control; MAFLD: Metabolic dysfunction-associated fatty liver disease; MASH: Metabolic dysfunction-associated steatohepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; STING: Stimulator of interferon genes.

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Citation: Zhou MY, Fang RF, Tang H, Xia XX, Xie Q, Yao DF, Sai WL, Yao M. Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction. World J Hepatol 2026; 18(7): 121423
URL: https://www.wjgnet.com/1948-5182/full/v18/i7/121423.htm
DOI: https://dx.doi.org/10.4254/wjh.121423

Zhou MY, Fang RF, Tang H, Xia XX, Xie Q, Yao DF, Sai WL, Yao M. Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction. World J Hepatol 2026; 18(7): 121423 [DOI: 10.4254/wjh.121423]

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