Saroglitazar ameliorates alcoholic liver disease and is associated with enhanced ethanol metabolism

Figure 5 Effect of saroglitazar on hepatic genes involved in alcohol metabolism. Liver mRNA expression of genes involved in alcohol metabolism was assessed by quantitative polymerase chain reaction. It shows the expression levels of key metabolic genes, including Cyp2E1, Adh and Aldh2, in liver tissue from mice treated with saroglitazar or vehicle. Data are presented as mean ± SEM (n = 8 for normal control and n = 9 disease control and treatments). Statistical analysis was performed using one-way analysis of variance followed by Dunnett’s multiple comparison test. ^cP < 0.001 vs disease control group. PO: Orally; OD: Once daily; BID: Twice daily; UDCA: Ursodeoxycholic acid.