Liver stiffness-based composite indices for compensated and decompensated cirrhosis in chronic hepatitis B

Table 5 Diagnostic performance of the proposed models and established indices for chronic hepatitis B, compensated cirrhosis, and decompensated cirrhosis

Disease	Model	Cut-off value	Sensitivity	Specificity	AUC	95%CI
CHB	A-index	> 4.60	0.86	1.00	0.948	0.900-0.997
	ALBI grade	> -2.85	0.69	0.61	0.656	0.534-0.778
Compensated liver cirrhosis	MAPTAL index	> 12.76	0.81	0.88	0.918	0.853-0.983
	APRI	> 0.56	0.70	0.94	0.895	0.818-0.972
	LPRI	> 4.32	0.93	0.85	0.942	0.887-0.997
	Fib-4 index	> 2.31	0.70	0.88	0.838	0.735-0.941
	S index	> 0.11	0.78	0.82	0.854	0.758-0.949
Decompensated liver cirrhosis	APTAL index	> 11.39	0.87	0.94	0.968	0.930-1.007
	APRI	> 0.45	0.91	0.88	0.929	0.855-1.002
	LPRI	> 4.85	0.96	0.88	0.949	0.873-1.024
	Fib-4 index	> 3.76	0.74	0.97	0.938	0.880-0.996
	S index	> 0.11	0.83	0.82	0.877	0.780-0.974

A-index = 0.101 × alanine aminotransferase (ALT); MAPTAL index = -2.732 × male + 0.125 × age - 0.039 × platelet count (PLT) + 1.813 × total cholesterol (TC) + 0.098 × ALT + 0.518 × liver stiffness measurement (LSM); APTAL index = 0.204 × age - 0.05 × PLT + 2.188 × TC - 0.183 × albumin + 0.467 × LSM. CHB: Chronic hepatitis B; ALBI grade: Albumin-bilirubin grade; APRI: Aspartate Platelet Ratio Index; LPRI: LSM to Platelet Ratio Index; Fib-4: Fibrosis-4; AUC: Area under the curve; CI: Confidence interval.