Liver stiffness-based composite indices for compensated and decompensated cirrhosis in chronic hepatitis B

Table 1 Baseline characteristics of chronic hepatitis B virus-infected patients by disease stage

Indicator	Chronic HBV infection group (n = 33)		CHB group (n = 49)	Compensated liver cirrhosis group (n = 27)	Decompensated liver cirrhosis group (n = 23)	P value
Age (years)	Median (IQR)	46 (22.50)	37 (19.50)	52 (23.00)	56 (8.00)	< 0.001
Height (m)	Median (IQR)	1.67 (0.11)	1.70 (0.14)	1.70 (0.13)	1.65 (0.14)	0.054
Weight (kg)	mean ± SD	66.06 ± 10.85	69.62 ± 14.72	71.76 ± 14.86	67.24 ± 14.21	0.438
BMI (kg/m2)	mean ± SD	24.12 ± 3.88	24.39 ± 4.24	24.86 ± 4.10	24.72 ± 3.69	0.718
ALT (IU/L)	Median (IQR)	20.50 (12.00)	126.30 (263.90)	36.90 (31.70)	26.80 (16.10)	< 0.001
AST (IU/L)	Median (IQR)	22.50 (7.15)	80.00 (99.15)	35.30 (27.10)	35.30 (37.30)	< 0.001
ALP (IU/L)	Median (IQR)	76.50 (34.40)	97.50 (53.50)	89.00 (31.40)	78.30 (57.40)	0.009
GGT (IU/L)	Median (IQR)	18.20 (13.35)	95.60 (124.75)	35.40 (48.90)	24.40 (58.70)	< 0.001
TBA (µmol/L)	Median (IQR)	3.70 (5.60)	5.50 (11.70)	10.30 (22.20)	12.30 (42.90)	0.001
T-Bil (µmol/L)	Median (IQR)	12.60 (7.60)	18.60 (13.65)	20.60 (15.40)	21.70 (20.00)	< 0.001
D-Bil (µmol/L)	Median (IQR)	2.80 (1.45)	4.40 (4.25)	5.10 (3.30)	5.10 (3.80)	< 0.001
I-Bil (µmol/L)	Median (IQR)	9.70 (6.25)	14.60 (10.20)	15.30 (12.30)	16.10 (16.50)	0.001
TC (mmol/L)	Median (IQR)	4.39 (1.28)	4.14 (1.41)	3.74 (1.27)	3.13 (1.44)	0.002
TG (mmol/L)	Median (IQR)	0.93 (0.71)	1.27 (0.99)	0.93 (0.34)	0.77 (0.50)	0.001
ALB (g/L)	Median (IQR)	43.30 (5.75)	41.90 (5.65)	38.60 (8.00)	34.30 (9.50)	< 0.001
PLT (109/L)	mean ± SD	193.52 ± 61.26	170.22 ± 61.06	116.37 ± 55.54	80.00 ± 48.25	< 0.001
PT (seconds)	Median (IQR)	11.30 (1.00)	11.60 (1.60)	12.30 (2.50)	13.20 (2.20)	< 0.001
PTA (%)	mean ± SD	95.61 ± 10.23	92.24 ± 16.05	80.22 ± 15.72	73.83 ± 15.24	< 0.001
LSM (KPa)	Median (IQR)	5.00 (1.70)	8.40 (8.15)	13.30 (15.90)	16.60 (19.00)	< 0.001
CAP (dB/m)	Median (IQR)	216.00 (51.50)	222.00 (76.50)	222.00 (78.00)	208.00 (52.00)	0.466
Gender	Male, n (%)	16 (48.48)	35 (71.43)	20 (74.07)	11 (47.83)	0.045
	Female, n (%)	17 (51.52)	14 (28.57)	7 (25.93)	12 (52.17)

CHB: Chronic hepatitis B; HBV: Hepatitis B virus; BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transpeptidase; TBA: Total bile acid; T-Bil: Total bilirubin; D-Bil: Direct bilirubin; I-Bil: Indirect bilirubin; TC: Total cholesterol; TG: Triglyceride; ALB: Albumin; PLT: Platelet count; PT: Prothrombin time; PTA: Prothrombin activity; LSM: Liver stiffness measurement; CAP: Controlled attenuation parameter; IQR: Inter-quartile range.