Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway

doi:10.4254/wjh.120427

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jun 27, 2026; 18(6): 120427
Published online Jun 27, 2026. doi: 10.4254/wjh.120427

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Figure 6 Silencing ARNT2 inhibits UBE2Z expression, which is associated with hepatocellular carcinoma status and poor prognosis. A: Expression patterns of input genes in liver hepatocellular carcinoma (top 25) were analyzed using the ULCAN online tool; B: The correlation between ARNT2 and UBE2Z expression was analyzed using the ULCAN online tool; C: The association between ARNT2 expression and survival was analyzed using the ULCAN online tool; D-H: UBE2Z expression in liver hepatocellular carcinoma under different clinical conditions was assessed using the ULCAN online tool; I: UBE2Z levels were analyzed by Western blot; J: UBE2Z expression was evaluated using immunohistochemical staining. Results are presented as the mean ± SD, n = 3. ^bP < 0.01; ^cP < 0.001. LIHC: Liver hepatocellular carcinoma.

Citation: Yin DD, Jiang WY, Huang YT, Zhou SP, Zhang YC. Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway. World J Hepatol 2026; 18(6): 120427
URL: https://www.wjgnet.com/1948-5182/full/v18/i6/120427.htm
DOI: https://dx.doi.org/10.4254/wjh.120427

Yin DD, Jiang WY, Huang YT, Zhou SP, Zhang YC. Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway. World J Hepatol 2026; 18(6): 120427 [DOI: 10.4254/wjh.120427]

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