Recurrence after surgery for hepatocellular carcinoma: “The seed and the soil” - a multicentre retrospective cohort study

doi:10.4254/wjh.120213

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jun 27, 2026; 18(6): 120213
Published online Jun 27, 2026. doi: 10.4254/wjh.120213

Table 3 Recurrence risk according to the number of pre-operative risk factors (cirrhosis, albumin-bilirubin grade ≥ 2, Barcelona Clinic Liver Cancer staging system stage B/C)

Number of risk factors	Criteria present	aHR (95%CI)	P value	n (%)
0	None	Reference	Reference	60 (26)
1	Any one of: Cirrhosis, ALBI ≥ 2, or BCLC stage B/C	2.74 (1.57-4.76)	< 0.001	102 (43)
2	Any two	4.32 (2.29-8.12)	< 0.001	62 (26)
3	All three	7.53 (2.47-22.93)	< 0.001	10 (4)

aHR: Adjusted hazard ratio; CI: Confidence interval; ALBI: Albumin-bilirubin; BCLC: Barcelona Clinic Liver Cancer.

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Citation: Blackmore C, Lockart I, Gandy G, Yeoh YKJ, Flynn C, Prince DS, Dore G, Danta M, George J, Alavi M, Farooque Y, Hajarizadeh B, Levy MT. Recurrence after surgery for hepatocellular carcinoma: “The seed and the soil” - a multicentre retrospective cohort study. World J Hepatol 2026; 18(6): 120213
URL: https://www.wjgnet.com/1948-5182/full/v18/i6/120213.htm
DOI: https://dx.doi.org/10.4254/wjh.120213

Blackmore C, Lockart I, Gandy G, Yeoh YKJ, Flynn C, Prince DS, Dore G, Danta M, George J, Alavi M, Farooque Y, Hajarizadeh B, Levy MT. Recurrence after surgery for hepatocellular carcinoma: “The seed and the soil” - a multicentre retrospective cohort study. World J Hepatol 2026; 18(6): 120213 [DOI: 10.4254/wjh.120213]

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