Differential impact of high-fructose and ethanol diets on early steatohepatitis and hepatic melanocortin-4 receptor responses in rats

doi:10.4254/wjh.119792

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jun 27, 2026; 18(6): 119792
Published online Jun 27, 2026. doi: 10.4254/wjh.119792

Table 1 Diet composition

Component (% kcal)	Control (chow, solid) (%)	HFD (liquid) (%)	HF-EFr (liquid) (%)	HFrD (liquid) (%)
Fat	13	35	35	18
Carbohydrate	58 (starch/complex)	47% (maltose/dextrin)	30 fructose	70 fructose
Protein	Approximately 29	Approximately 18	Approximately 15	Approximately 12
Ethanol (EtOH)	0	0	Approximately 30	0
Total kcal	100	100	100	100

HFD: High-fat diet; HF-EFr: High-fat plus ethanol and fructose; HFrD: High-fructose diet.

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Citation: Alwahsh SM, Xu M, Nabulsi M, Mihm S, Alzahrani FA, Ramadori GP. Differential impact of high-fructose and ethanol diets on early steatohepatitis and hepatic melanocortin-4 receptor responses in rats. World J Hepatol 2026; 18(6): 119792
URL: https://www.wjgnet.com/1948-5182/full/v18/i6/119792.htm
DOI: https://dx.doi.org/10.4254/wjh.119792

Alwahsh SM, Xu M, Nabulsi M, Mihm S, Alzahrani FA, Ramadori GP. Differential impact of high-fructose and ethanol diets on early steatohepatitis and hepatic melanocortin-4 receptor responses in rats. World J Hepatol 2026; 18(6): 119792 [DOI: 10.4254/wjh.119792]

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