Routine laboratory model for identifying significant fibrosis in chronic hepatitis B

Figure 3 Model performance across cohorts. Receiver operating characteristic curves in the development cohort, the biopsy-confirmed external cohort (First Affiliated Hospital of Zhejiang University), and the population-based exploratory cohort (National Health and Nutrition Examination Survey, surrogate-labeled). The model demonstrated good discrimination across all datasets. In National Health and Nutrition Examination Survey, discrimination was evaluated against fibrosis status defined by aspartate aminotransferase to platelet ratio index/fibrosis-4-based surrogate criteria rather than histological confirmation. The dashed diagonal line represents no discrimination. AUC: Area under the curve; CI: Confidence interval.