Routine laboratory model for identifying significant fibrosis in chronic hepatitis B

Figure 2 Performance and reclassification of the model within the fibrosis-4 indeterminate zone. A: Distribution of model-assigned risk strata among patients within the fibrosis-4 indeterminate (gray) zone (n = 129). Among these individuals, 54 (41.9%) were classified as lower risk, 39 (30.2%) remained in an intermediate range, and 36 (27.9%) were classified as higher risk. The observed prevalence of significant fibrosis (S ≥ 2) increased across strata (13.0%, 35.9%, and 75.0%, respectively); B: Receiver operating characteristic curve of the model restricted to the fibrosis-4 indeterminate subgroup, demonstrating preserved discrimination (area under the curve = 0.821, 95% confidence interval: 0.737-0.895). The dashed diagonal line represents no discrimination. AUC: Area under the curve; CI: Confidence interval; FIB-4: Fibrosis-4.