Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota

doi:10.4254/wjh.118607

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jun 27, 2026; 18(6): 118607
Published online Jun 27, 2026. doi: 10.4254/wjh.118607

Table 2 Effects of Yinchen Wuling San on intestinal short-chain fatty acids in rats (n = 6), mean ± SD

Indicator (μg/g)	Control (n = 6)	Model (n = 6)	YCWLS (n = 6)	CBLT (n = 6)	F value	P value	Effect size(η²)
Acetic	1368.33 ± 182.89	1360.36 ± 408.36	1620.63 ± 230.69	1467.54 ± 465.96	0.749	0.536	0.10
Propionic	445.04 ± 66.09	451.29 ± 114.76	521.80 ± 78.19	475.62 ± 183.33	0.509	0.681	0.07
Isobutyric	67.17 ± 10.69	69.11 ± 13.82	79.71 ± 6.32	73.83 ± 30.12	0.599	0.623	0.08
Butyric	434.14 ± 104.89	423.88 ± 69.45	471.64 ± 99.79	316.71 ± 94.09	3.064	0.052	0.31
Isovaleric	49.32 ± 8.57	51.34 ± 12.01	59.52 ± 5.15	56.20 ± 28.81	0.478	0.701	0.07
Valeric	71.48 ± 10.88	63.45 ± 17.00	82.95 ± 12.28	70.42 ± 31.56	1.008	0.41	0.13
Caproic	13.19 ± 6.82	6.56 ± 8.74	5.73 ± 4.25	2.88 ± 3.81	2.937	0.058	0.31

YCWLS: Yinchen Wuling San; CBLT: Bifidobacterium quadruple live bacteria tablets.

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Citation: Zhang Y, Liu J, Huang AS, Wang YF, Cao J, Li ML, Shi DD, Hu YL, Deng Q, Long P, Ai BC. Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota. World J Hepatol 2026; 18(6): 118607
URL: https://www.wjgnet.com/1948-5182/full/v18/i6/118607.htm
DOI: https://dx.doi.org/10.4254/wjh.118607

Zhang Y, Liu J, Huang AS, Wang YF, Cao J, Li ML, Shi DD, Hu YL, Deng Q, Long P, Ai BC. Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota. World J Hepatol 2026; 18(6): 118607 [DOI: 10.4254/wjh.118607]

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