Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota

Table 1 Identification of blood components in Yinchen Wuling San via ultra-high performance liquid chromatography-tandem mass spectrometry (top 30)

English name	Formula	MZMED	RTMED	MZPPM	Adduct
L-histidine	C6H9N3O2	155.0700431	94.11205	6.874707376	[M]+
Diosmin	C28H32O15	591.1671031	270.3345	6.287430271	[M-H2O+H]+
Citronellyl acetate	C12H22O2	237.1230112	95.1271	8.901819088	[M+K]+
Synephrine	C9H13NO2	150.0910279	128.6115	2.005831636	[M-H2O+H]+
3,5,5-trimethyl-4beta-hydroxy-4-[3-(beta-D-glucopyranosyloxy)-1-butenyl]-2-cyclohexene-1-one	C19H30O8	387.2001167	292.777	3.055977289	[M+H]+
4-methylcyclohexanol	C7H14O	115.1114776	698.5315	1.931686223	[M+H]+
Raffinose	C18H32O16	543.1303366	99.9993	3.417948475	[M+K]+
5-[(Z)-14-(3,5-dihydroxyphenyl)tetradec-10-enyl]benzene-1,3-diol	C26H36O4	430.2945952	419.392	1.544505078	[M+NH4]+
3-amino-2-oxopropyl phosphate	C3H8NO5P	170.0190785	71.55605	12.4780473	[M+H]+
Piscerythramine	C26H29NO6	452.2095794	260.426	6.367520943	[M+H]+
Glutaric acid	C5H8O4	153.0163698	105.836	3.627350757	[M+Na-2H]-
2-hydroxy-6-(4-hydroxy-2-methoxy-6-methoxycarbonyl-phenoxy)-4-methyl-benzoic acid	C17H16O8	348.0799644	368.895	14.51705114	[M]-
Rosmarinic acid	C18H16O8	419.0980201	286.017	0.710820202	[M+CH3COO]-
4-vinylphenol	C8H8O	118.0408611	264.935	13.16392975	[M-2H]2-
9-hydroxy-1,2,11,15,15-pentamethyl-5-(4,5,6-trihydroxy-6-methylheptan-2-yl)-6-oxapentacyclo[8.8.0.02,7.05,7.011,16]octadecan-14-one	C30H50O6	505.3555925	461.842	4.140567905	[M-H]-
Butyl (S)-3-hydroxybutyrate [arabinosyl-(1->6)-glucoside]	C19H34O12	453.1918418	288.4025	13.14703991	[M-H]-
2-phenyllactic acid	C9H10O3	165.0554395	309.942	1.687130633	[M-H]-
4,8-dihydroxy-4a-methyl-7-propan-2-yl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-one	C14H24O3	239.1650858	358.499	0.895579869	[M-H]-
2-[3-hydroxy-5-(2-hydroxyethyl)phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol	C14H20O8	315.1083127	207.883	0.911803197	[M-H]-
Eucalyptin	C19H18O5	325.1076596	398.125	1.662114327	[M-H]-
Neotenone	C19H14O6	337.0745352	364.9755	8.114509277	[M-H]-
3-[3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-3H-2-benzofuran-1-one	C18H24O8	367.1380078	299.96	5.153920718	[M-H]-
1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid + hydroxy (RP1)	C13H14N2O3	307.1265085	249.29	9.226811951	[M+CH3COO+2H]+
Capillartemisin_B-2H (RP1)	C19H22O4	353.1182522	383.275	9.302870377	[M+K]+
Ganoderic_acid_Mf-2H (RP1)	C32H46O5	510.339525	450.301	10.77817249	[M]+
Camphor + hydroxy (RP2)	C10H16O2	229.1410249	291.012	12.67707909	[M+CH3COO+2H]+
Ephedroxane + hydroxy (RP1)	C11H13NO3	230.0807749	297.288	8.39529186	[M+Na]+
Alnustone + hydroxy (RP1)	C19H18O2	339.1562425	420.569	9.840014502	[M+CH3COO+2H]+
N-feruloylputrescine + glucuronide (RP1)	C20H28N2O9	440.1843138	308.2965	12.1162193	[M]+
Darutigenol + sulfate (RP1)	C20H34O6S	805.4321369	419.14	11.97043215	[2M+H]+