Liver stiffness-platelet ratio index and machine learning models for the noninvasive diagnosis of significant fibrosis in chronic hepatitis B

doi:10.4254/wjh.v18.i5.119798

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 119798
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.119798

Table 1 Baseline characteristics of the training and validation datasets, n (%)/median (interquartile range)

Variables	Training set (n = 768)	Validation set (n = 330)	P values
Gender (male/female)	Male 473 (61.6)	Male 211 (63.9)	0.50
Gender (male/female)	Female 295 (38.4%)	Female 119 (36.1%)	0.50
Age (years)	36.00 (30.00, 44.25)	37.00 (30.25, 45.75)	0.56
Weight (kg)	61.00 (53.00, 69.00)	61.80 (54.00, 69.00)	0.85
Height (cm)	167.00 (160.00, 171.00)	168.00 (160.00, 173.00)	0.27
Hepatitis B virus DNA (log10 IU/mL)	5.90 (3.78, 7.63)	6.14 (3.56, 7.62)	0.59
Hepatitis B surface antigen (log10 IU/mL)	3.59 (3.07, 4.22)	3.57 (3.04, 4.32)	0.76
Hepatitis B surface antibody (mIU/mL)	0.19 (0.00, 1.10)	0.10 (0.00, 1.00)	0.21
Hepatitis B e antigen (COI)	0.59 (0.11, 700.00)	0.50 (0.17, 700.00)	0.86
Hepatitis B e antibody (COI)	0.32 (0.01, 13.39)	0.22 (0.01, 7.99)	0.26
Hepatitis B core antibody (COI)	7.95 (0.01, 9.27)	7.66 (0.01, 9.35)	0.71
White blood cell (10⁹/L)	5.30 (4.50, 6.20)	5.30 (4.40, 6.10)	0.84
Neutrophil Abs. count (10⁹/L)	2.90 (2.40, 3.60)	3.00 (2.40, 3.70)	0.45
Hemoglobin (g/L)	145.00 (132.00, 155.25)	146.00 (132.25, 156.00)	0.67
Platelet (10⁹/L)	202.00 (168.00, 239.00)	195.00 (165.00, 229.00)	0.02
Prothrombin time (seconds)	13.10 (12.62, 13.70)	13.10 (12.60, 13.70)	0.91
International normalized ratio	1.01 (0.97, 1.06)	1.02 (0.97, 1.06)	0.62
Albumin (g/L)	44.00 (42.00, 46.00)	44.00 (42.00, 46.00)	0.52
Globulin (g/L)	31.00 (28.00, 34.00)	30.00 (27.00, 34.00)	0.62
Total bilirubin (μmol/L)	16.05 (11.80, 21.50)	15.50 (12.10, 21.10)	0.88
Direct bilirubin (μmol/L)	4.85 (3.00, 7.20)	4.80 (2.90, 7.47)	0.92
Alanine aminotransferase (U/L)	68.00 (44.00, 116.00)	68.00 (47.00, 118.00)	0.65
Aspartate aminotransferase (U/L)	49.00 (27.75, 94.00)	44.00 (25.00, 89.75)	0.17
Gamma-glutamyl transferase (U/L)	33.00 (21.00, 62.00)	31.50 (21.00, 56.00)	0.44
Alkaline phosphatase (U/L)	63.00 (33.00, 83.00)	61.00 (31.25, 81.00)	0.64
Alpha-fetoprotein (ng/mL)	2.95 (1.75, 5.55)	2.79 (1.82, 4.64)	0.51
Liver stiffness measurement (kPa)	7.40 (5.60, 10.60)	7.30 (5.50, 10.20)	0.70

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Citation: Lin JY, Ai ZX, Luo MJ, Su LZ, Gao XG, Jiang HL, Lin JQ, Zhang HY, Sun YY, Yu HT, Zhang L, Gong XQ. Liver stiffness-platelet ratio index and machine learning models for the noninvasive diagnosis of significant fibrosis in chronic hepatitis B. World J Hepatol 2026; 18(5): 119798
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/119798.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.119798

Lin JY, Ai ZX, Luo MJ, Su LZ, Gao XG, Jiang HL, Lin JQ, Zhang HY, Sun YY, Yu HT, Zhang L, Gong XQ. Liver stiffness-platelet ratio index and machine learning models for the noninvasive diagnosis of significant fibrosis in chronic hepatitis B. World J Hepatol 2026; 18(5): 119798 [DOI: 10.4254/wjh.v18.i5.119798]

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