Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report

doi:10.4254/wjh.v18.i5.118469

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 118469
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118469

Table 3 Assessment of hepatic biopsy findings before and during enzyme replacement therapy

Evaluation time	Ishak fibrosis score	Lobular inflammation	Macrovesicular steatosis	Microvesicular steatosis	Portal inflammation
Before treatment	3	2	0	4	3
Treatment week 52	2	1	1	2	1
Treatment week 104	1	1	0	4	2

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Citation: Kaplan I, Kor D, Bulut FD, Tumgor G, Alabaz D, Önenli Mungan N. Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report. World J Hepatol 2026; 18(5): 118469
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/118469.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.118469

Kaplan I, Kor D, Bulut FD, Tumgor G, Alabaz D, Önenli Mungan N. Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report. World J Hepatol 2026; 18(5): 118469 [DOI: 10.4254/wjh.v18.i5.118469]

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