Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging

Table 2 Laboratory characteristics of study groups, mean ± SD

Variable	Overt hypothyroidism (A)	Subclinical hypothyroidism (B)	Control (C)	P value	Pairwise comparison
TSH (mIU/L)	27.6 ± 29	7.1 ± 2.4	2.5 ± 1	< 0.001	A vs B: < 0.001
					A vs C: < 0.001
					B vs C: 0.553
FT4 (ng/dL)	1 ± 0.4	1.1 ± 0.2	1.2 ± 0.2	< 0.001	A vs C: < 0.001
					B vs C: 0.009
					A vs B: 0.250
ALT (U/L)	35 ± 64.5	18.7 ± 10.2	20.6 ± 9.5	0.077	A vs B: 0.115
					A vs C: 0.203
					B vs C: 1.000
AST (U/L)	29.8 ± 33.9	20.8 ±7.4	19.7 ± 6.5	0.033	A vs B: 0.100
					A vs C: 0.051
					B vs C: 1.000
Total cholesterol (mg/dL)	206.8 ± 37.9	178 ± 30.8	151.6 ± 35.5	< 0.001	A vs B: < 0.001
					A vs C: < 0.001
					B vs C: < 0.001
High density lipoprotein (mg/dL)	50.4 ± 12.5	48.9 ± 12.5	46.3 ± 18.7	0.381	A vs B: 1.000
					A vs C: 0.510
					B vs C: 1.000
Low density lipoprotein (mg/dL)	130.8 ± 34.2	110.4 ± 26.3	87.2 ± 36.6	< 0.001	A vs B: 0.008
					A vs C: < 0.001
					B vs C: 0.002
Triglycerides (mg/dL), median (range)	107 (31-356)	84 (31-322)	73.5 (37-344)	0.004	A vs B: 0.032
					A vs C: 0.005
					B vs C: 0.564

P value < 0.05 is considered significant. TSH: Thyroid-stimulating hormone; FT4: Free thyroxine; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.