Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging

doi:10.4254/wjh.v18.i5.117441

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 117441
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117441

Table 12 Receiver-operating characteristic curve, with sensitivity 83% and specifity 89%, showing thyroid-stimulating hormone > 6.1 (mIU/L) is associated with a higher risk of metabolic dysfunction-associated steatotic liver disease development

Variable	Cut-off point	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC	95%CI for AUC	P value
TSH (mIU/L)	> 6.1	83	89	86	87	0.88	0.82-0.93	< 0.001

PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the curve; CI: Confidence interval TSH: Thyroid-stimulating hormone.

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Citation: Sholkamy A, El-Meligui A, H Saad E, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; 18(5): 117441
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/117441.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.117441

Sholkamy A, El-Meligui A, H Saad E, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; 18(5): 117441 [DOI: 10.4254/wjh.v18.i5.117441]

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