Congenital porto-sinusoidal vascular disorder-induced portal hypertension: A comprehensive review based on a classic clinical case

Figure 2 The potential pathophysiological mechanisms of congenital portal hypertension essentially involve abnormalities in the structure or hemodynamics of the portal venous system. Including: Congenital venous developmental defects, congenital hepatic fibrosis, perinatal venous thrombosis, molecular genetic factors such as gene mutations, and environmental factors such as perinatal infections and drug exposure. Additionally, complications arising in related sites due to congenital portal hypertension may occur. FBN1: Fibrillin 1; NOTCH1: Notch receptor 1; ACVRL1: Activin A receptor like type 1; MRI: Magnetic resonance imaging.