Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 7 Univariate Logistic regression analysis of independent factors associated with liver cirrhosis

Factors	OR (95%CI)¹	P value²
Age	1.060 (1.03-1.08)	0.000
Gender	0.916 (0.53-1.8)	0.916
BMI	1.07 (1.01-1.13)	0.017
HCV-RNA log₁₀	0.96 (0.75-1.24)	0.741
ALT	1.007 (1.00-1.01)	0.017
AST	1.000 (0.99-1.00)	0.891
Total bilirubin	1.196 (0.82-1.74)	0.352
IFI16 rs1057028 (TT)	1.22 (0.56-2.67)	0.607

¹The overall model explains that predictors have 67% variance in disease risk.

²Age, body mass index and alanine aminotransferase levels were statistically significant independent predictors of liver cirrhosis.

Nagelkerke R² = 0.67, -2 Log likelihood = 320.935 and P = 0.07. BMI: Body mass index; HCV: Hepatitis C virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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