Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 6 Association of AIM2 (rs2814770) with different baseline characteristics of hepatitis C virus induced liver fibrosis patients

Measure	AIM2 (rs2814770) recessive model		P value¹
Measure	C/C + C/T (n = 101)	T/T (n = 39)	P value¹
Age (years)	38 (31-48.7)	40 (30-48)	0.54
Gender
Female	54 (77.1)	16 (22.9)	0.18
Male	47 (67.1)	23 (32.9)	0.18
BMI (kg/m²)	27.2 (23.8-30.9)	24.5 (22.4-29.4)	0.05
HCV-RNA log₁₀ (IU/mL)	4.7 (3.8-5.3)	4.67 (3.9-5.4)	0.89
ALT (IU/L)	57 (37-89.5)	61 (42-98)	0.21
AST (IU/L)	53 (40.2-80.7)	62.5 (35-86.2)	0.37
Bilirubin (mg/dL)	0.8 (0.7-0.9)	0.8 (0.7-0.95)	0.45

¹Body mass index were significant predictor of liver fibrosis risk.

Data were showed as n (%) or median (interquartile range). BMI: Body mass index; HCV: Hepatitis C virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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