Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 5 Association of IFI16 (rs1057028) with different baseline clinical and laboratory characteristics of hepatitis C virus induced liver fibrosis patients under recessive model

Measure	IFI16 (rs1057028) recessive model		P value
Measure	A/A + A/T (n = 309)	T/T (n = 69)	P value
Age (years)	40 (32-50)	40 (33-45)	0.87
Gender
Female	153 (80.95)	36 (19.05)	0.7
Male	155 (82.45)	33 (17.55)	0.7
BMI (kg/m²)	26.85 (24-30)	26.8 (24-30.7)	0.68
HCV-RNA log₁₀ (IU/mL)	4.57 (3.7-5.4)	4.75 (5.4-3.7)	0.86
ALT (IU/L)	60 (39-88)	57 (42-94.5)	0.69
AST (IU/L)	56 (40-83)	51 (38.5-83.5)	0.63
Bilirubin (mg/dL)	0.8 (0.7-0.9)	0.8 (0.7-0.95)	0.22

Data were showed as n (%) or median (interquartile range). BMI: Body mass index; HCV: Hepatitis C virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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