Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 4 Combined genotype analysis of IFI16 (rs1057028) and AIM2 (rs2814770) variant associated with risk of liver fibrosis

Combined genotypes rs1057028 A/T, rs2814770 C/T	Frequency	Case, control ratios	OR (95%CI interval)	P value corrected¹
A-C	0.3673	0.2595, 0.4703	1.00	-
A-T	0.2874	0.2905, 0.294	2.60 (1.16-5.86)	0.022
T-T	0.2054	0.231, 0.1703	2.41 (0.98-5.91)	0.057
T-C	0.1399	0.219, 0.0654	2.40 (0.74-7.82)	0.15

¹The combined effect of both A allele of IFI16 rs1057028 and T allele of AIM2 rs2814770 were significant predictors of liver fibrosis risk.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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