Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 3 Allele/genotypic distribution of AIM2 (rs2814770) among chronic hepatitis C patients

SNP	Model	Genotype	CHC patients		OR (95%CI)	P value¹	AIC
SNP	Model	Genotype	Fibrosis grade (F0-F1), n = 70	Fibrosis grade, (F2-F4), n = 70	OR (95%CI)	P value¹	AIC
AIM2 rs2841770	Genotypic	C/C	24 (34.8)	17 (24.3)	1.00	0.05	125.3
		C/T	26 (37.7)	33 (47.1)	2.00 (0.66-6.09)
		T/T	19 (27.5)	20 (28.6)	4.86 (1.27-18.58)
	Allelic	C	75 (54)	67 (48)	1.00	0.40	NA
	Allelic	T	65 (46)	73 (52)	1.12 (0.79-2.01)	0.40	NA
	Dominant	C/C	24 (34.8)	17 (24.3)	1.00	0.058	125.5
	Dominant	C/T-T/T	45 (65.2)	53 (75.7)	2.66 (0.94-7.50)	0.058	125.5
	Recessive	C/C-C/T	50 (72.5)	50 (71.4)	1.00	0.038	124.8
	Recessive	T/T	19 (27.5)	20 (28.6)	3.13 (1.03-9.56)	0.038	124.8

¹Genotypic distribution and Recessive model were significantly associated with increased hepatic fibrosis risk.

SNP: Single nucleotide polymorphism; CHC: Chronic hepatitis C; AIC: Akaike Information Criterion; NA: Not available.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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