Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 2 Allele and genotype frequencies and association of IFI16 (rs1057028) polymorphism with advanced fibrosis (≥ F2), assuming different genetic models, n (%)

SNP	Model	Genotype	CHC patients		OR (95%CI)	P value	AIC
SNP	Model	Genotype	Fibrosis grade (F0-F1), n = 223	Fibrosis grade (F2-F4), n = 152	OR (95%CI)	P value	AIC
IFI16 (rs1057028)	Genotypic	A/A	125 (57.3)	76 (50.7)	1.00	0.14	463.7
		A/T	58 (26.6)	40 (26.7)	1.20 (0.71-2.03)
		T/T	35 (16.1)	34 (22.7)	1.81 (1.01-3.23)
	Allelic	A	316 (71)	196 (64)	1.00	0.91	NA
	Allelic	T	130 (29)	108 (36)	1.24 (0.91-0.68)	0.91	NA
	Dominant	A/A	125 (57.3)	76 (50.7)	1.00	0.12	463.2
	Dominant	A/T-T/T	93 (42.7)	74 (49.3)	1.43 (0.91-2.22)	0.12	463.2
	Recessive	A/A-A/T	183 (83.9)	116 (77.3)	1.00	0.06	462.1
	Recessive	T/T	35 (16.1)	34 (22.7)	1.70 (0.98-2.96)	0.06	462.1

SNP: Single nucleotide polymorphism; CHC: Chronic hepatitis C; AIC: Akaike Information Criterion; NA: Not available.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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