Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

doi:10.4254/wjh.v18.i5.116995

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. May 27, 2026; 18(5): 116995
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995

Table 1 Baseline demographic, clinical, laboratory features, fibrosis stage, and IFI16 (rs1057028) and AIM2 (rs2814770) genotypic and allelic frequency in the present study population

Characteristics	CHC patients (n = 378)
Age (years)	40 (32-50)
BMI (kg/m²)	26.8 (24-30)
HCV-RNA log₁₀ (IU/mL)	4.58 (3.75-5.41)
ALT (IU/L)	59 (41-88)
AST (IU/L)	55 (39.2-89.5)
Bilirubin (mg/dL)	0.8 (0.7-0.9)
Metavir staging
F0-F1	223 (59.5)
F2	17 (4.5)
F3	59 (15.7)
F4	76 (20.3)
IFI16 rs1057028 (n = 378)
AA	209 (55.3)
AT	100 (26.5)
TT	69 (18.3)
A	518 (69)
T	238 (31)
AIM2 rs2814770 (n = 140)
CC	41 (29.3)
CT	60 (42.9)
TT	39 (27.9)
C	142 (51)
T	138 (49)

Data were showed as n (%) or median (interquartile range). CHC: Chronic hepatitis C; BMI: Body mass index; HCV: Hepatitis C virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

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Citation: Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995
URL: https://www.wjgnet.com/1948-5182/full/v18/i5/116995.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i5.116995

Arshad I, Majid M, Rauff B, Amar A, Choudhery MS. Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients. World J Hepatol 2026; 18(5): 116995 [DOI: 10.4254/wjh.v18.i5.116995]

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