Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study

Table 7 Post-hoc analysis of aspartate aminotransferase to platelet ratio index, fibrosis-4 index, aspartate aminotransferase to alanine aminotransferase ratio and gamma-glutamyl transferase to platelet ratio index across different FibroScan-based stages (n = 627)

Analytical index	Comparison group	P value
APRI	F0-F1	1.000
APRI	F0-F2	< 0.01b
APRI	F1-F2	0.264
APRI	F0-F3	< 0.001a
APRI	F1-F3	< 0.001a
APRI	F2-F3	0.137
APRI	F0-F4	< 0.001a
APRI	F1-F4	< 0.001a
APRI	F2-F4	< 0.001a
APRI	F3-F4	< 0.001a
FIB-4	F0-F1	1.000
FIB-4	F0-F2	< 0.05c
FIB-4	F1-F2	0.137
FIB-4	F0-F3	< 0.001a
FIB-4	F1-F3	< 0.001a
FIB-4	F2-F3	< 0.001a
FIB-4	F0-F4	< 0.001a
FIB-4	F1-F4	< 0.001a
FIB-4	F2-F4	< 0.001a
FIB-4	F3-F4	0.082
AST/ALT	F0-F1	1.000
AST/ALT	F0-F2	1.000
AST/ALT	F1-F2	1.000
AST/ALT	F0-F3	0.164
AST/ALT	F1-F3	< 0.05c
AST/ALT	F2-F3	0.090
AST/ALT	F0-F4	< 0.01b
AST/ALT	F1-F4	< 0.01b
AST/ALT	F2-F4	< 0.01b
AST/ALT	F3-F4	1.0000
GPR	F0-F1	0.122
GPR	F0-F2	< 0.001a
GPR	F1-F2	< 0.05c
GPR	F0-F3	< 0.001a
GPR	F1-F3	< 0.001a
GPR	F2-F3	0.009b
GPR	F0-F4	< 0.001a
GPR	F1-F4	< 0.001a
GPR	F2-F4	< 0.001a
GPR	F3-F4	0.115

^aP < 0.001.

^bP < 0.01.

^cP < 0.05.

Post-hoc analysis was used to identify specifically which stages have significant differences. APRI: Aspartate aminotransferase to platelet ratio index; GPR: Gamma-glutamyl transferase to platelet ratio index; FIB-4: Fibrosis-4 index; AST/ALT: Aspartate aminotransferase to alanine aminotransferase ratio.