Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study

Table 10 Diagnostic performance of various indicators in differentiating F0 vs F1-F4 and F0-F2 vs F3-F4

Comparison	Indices	AUC (95%CI)	P value	Cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	DA (%)
F0 and F1-F4	APRI	0.736 (0.69-0.781)	< 0.001	1.45	66.6	70.6	89.1	36.9	67.5
	GPR	0.814 (0.774-0.853)	< 0.001	0.715	72.3	79.4	92.7	44.3	73.8
	FIB-4	0.743 (0.699-0.786)	< 0.001	2.395	67.4	74.3	90.4	38.7	68.9
	AST/ALT	0.553 (0.5-0.606)	0.028	0.825	43.8	68.4	83.3	25.2	49.1
F0-F2 and F3-F4	APRI	0.776 (0.741-0.812)	< 0.001	1.76	72.6	68.4	68.8	72.3	70.5
	GPR	0.828 (0.796-0.86)	< 0.001	0.715	87.6	64.4	70.2	84.4	75.8
	FIB-4	0.814 (0.781-0.848)	< 0.001	3.88	66.4	85	81	72.5	75.9
	AST/ALT	0.615 (0.571-0.659)	< 0.001	0.825	52.1	69.4	62	60.2	60.9

This table shows the diagnostic performance of different indicators in differentiating F0 vs F1-F4 and F0-F2 vs F3-F4. APRI: Aspartate aminotransferase to platelet ratio index; GPR: Gamma-glutamyl transferase to platelet ratio index; FIB-4: Fibrosis-4 index; AST/ALT: Aspartate aminotransferase to alanine aminotransferase ratio; AUC: Area under the curve; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; DA: Diagnostic accuracy.