Diagnostic accuracy of blood-based non-invasive tests for prediction of varices in pediatric portal-hypertension: A systematic review and meta-analysis

Table 3 Diagnostic accuracy of various blood-based parameters/indices for the prediction of any varices and clinically significant varices in pediatric portal hypertension

Index test	Target condition	No. of study cohorts	Pooled sensitivity (95%CI)	Pooled specificity (95%CI)	Diagnostic odds ratio (95%CI)	PLR (95%CI)	NLR (95%CI)	AUC	Pre-test probability (%)	Post-test probability (+) (%)	Post-test probability (-) (%)
APRI	EV	7	0.77 (0.71-0.83)	0.71 (0.65-0.77)	11.15 (4.75-33.09)	2.85 (2.06-4.07)	0.26 (0.11-0.46)	0.795	25	47	10
									50	73	24
									75	89	49
	CSV	10	0.72 (0.67-0.77)	0.61 (0.57-0.65)	5.91 (2.91-18.62)	2.23 (1.57-4.94)	0.38 (0.24-0.55)	0.776	25	38	13
									50	65	32
									75	85	58
Platelet count	EV	5	0.69 (0.63-0.75)	0.77 (0.69-0.83)	9.23 (3.40-25.67)	3.30 (1.94-6.34)	0.36 (0.19-0.62)	0.834	25	50	12
									50	75	29
									75	90	55
	CSV	7	0.66 (0.59-0.72)	0.72 (0.67-0.76)	4.25 (1.95-8.56)	2.1 (1.38-3.14)	0.5 (0.33-0.71)	0.714	25	61	5
									50	83	15
									75	93	34
CPR	EV	4	0.78 (0.71-0.83)	0.80 (0.71-0.86)	12.91 (5.72-28.50)	3.68 (2.14-6.17)	0.29 (0.19-0.43)	0.848	25	70	6
									50	87	17
									75	95	38
	CSV	8	0.62 (0.56-0.68)	0.65 (0.59-0.70)	3.76 (1.74-8.40)	2.0 (1.35-3.26)	0.54 (0.32-0.79)	0.717	25	37	16
									50	64	37
									75	84	64
VPR	CSV	7	0.79 (0.73-0.84)	0.65 (0.60-0.70)	9.19 (4.06-21.7)	2.64 (1.73-5.11)	0.29 (0.19-0.44)	0.864	25	43	10
									50	70	24
									75	87	49
K-VaPS	CSV	5	0.52 (0.45-0.59)	0.72 (0.63-0.79)	2.43 (0.72-8.17)	1.72 (0.78-3.16)	0.72 (0.36-1.08)	0.727	25	38	18
									50	65	40
									75	85	67

EV: Esophageal/gastric varices; CSV: Clinically significant varices; APRI: Aspartate aminotransferase to platelet ratio index; CPR: Clinical prediction rule; VPR: Varices prediction rule; K-VaPS: King’s variceal prediction score; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; AUC: Area under receiver operating characteristic curve.